More than 30 mutations in the POLH gene have been found to cause the variant type of xeroderma pigmentosum (XP-V). Like the other forms of xeroderma pigmentosum, XP-V is characterized by an increased sensitivity to UV rays from sunlight. Superpolh izvaja športne programe za otroke in programe za odrasle.
Kot pri ostalih predstavnikih skupine jim sekalci rastejo vse življenje, zato jih morajo neprestano uporabljati. UniProtKB/Swiss-Prot: POLH_HUMAN:. The catalytic core consists of fingers, palm and thumb subdomains, but the fingers and thumb subdomains are much smaller than in high-fidelity polymerases; residues from five sequence motifs of the Y-family cluster around an active site cleft that can accommodate DNA and nucleotide substrates with relaxed geometric constraints, with consequently higher rates ... Xeroderma pigmentosum.